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They were separated as isopropylidene derivatives and the syn isomer 15 was subjected to ozonolysis and oxidation to give acid 16

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The deficiency was more severe than expected People with advanced B12 deficiency, especially with neurological symptoms, often feel rough at the start of treatment because the underlying problem was significant

Statements Ethics statement This study was carried out in strict accordance with recommendations of the National Institutes of Health guide for the care and use of Laboratory animals

possible amelioration of neurotoxicity by Carnosine, with special reference to Parkinsons disease